Rejuvenation & Skin Quality EnhancementPolynucleotides are an advanced bio-stimulating treatment designed to promote overall skin rejuvenation. They are an ideal option for skin that requires essential support and not just surface-level hydration.
What Are Polynucleotides?
Polynucleotides (PN/PDRN) are pure, biocompatible DNA molecules that have the ability to stimulate the skin’s natural regeneration mechanisms.
When injected into the superficial layers of the skin, they act as biostimulators that boost collagen production, support cellular renewal, improve microcirculation and increase dermal density.
Benefits
Polynucleotides enhance the skin’s natural regenerative processes, offering gradual and substantial improvement in skin quality.
Key benefits include:
- increased elasticity and dermal density
- improved texture and fine lines
- brighter and more even complexion
- enhanced hydration and natural glow
- reduced dullness and signs of fatigue
Polynucleotide Treatment
This treatment does not alter facial features, does not add volume and is not used as a filler. Its purpose is to improve the structure, quality and function of the skin at a deeper level.
Which Skin Concerns Does It Address?
Polynucleotide therapy is recommended when the skin shows loss of elasticity, dullness, dehydration, fine lines, mild laxity or uneven texture.
It is particularly effective on skin with reduced density, especially in the under-eye area and the face.
Polynucleotides for the Under-Eye Area
The under-eye region has thin, delicate skin that often shows dehydration and surface laxity. Polynucleotides are an excellent option, as they reinforce tissue density and structure without adding volume, providing a brighter and more refreshed appearance.
Treatment Procedure – Step by Step
The procedure is short and tailored to the individual needs of the patient’s skin.
Clinical evaluation
The doctor examines the area, identifies the needs of the skin and determines the appropriate protocol.
Skin preparation
The skin is cleansed and, if necessary, a topical anesthetic is applied for greater comfort.
Targeted micro-injections
Polynucleotides are injected into specific points of the superficial dermal layers in order to act directly on renewal mechanisms.
Completion & aftercare
The session ends with a soothing application. The patient may return to daily activities immediately.
Plastic Surgeon Dr. Konstantinos Ch. Makrygiorgis
Plastic surgery is the perfect blend of science and art, of passion and technology. Our primary goal is to help you achieve your personal aesthetic aspirations, while also providing you with clear and honest guidance for your benefit. Perfectionists by nature, we are fully committed to your vision to how you imagine your best self. Because perfection is a deeply personal matter, and it doesn’t come in one single form.
Learn more about the DoctorTreatment Results
Polynucleotides provide gradual, natural and high-quality results, as they act on the skin’s regeneration mechanisms.
When are results visible?
Initial improvements become noticeable within 7–10 days, with the skin appearing more hydrated and even. Full results develop gradually over the next 4–6 weeks as collagen production increases and tissue density improves.
How long do results last?
Results typically last 6–9 months, depending on skin type and treatment protocol. With regular maintenance sessions, improvement becomes even more stable and long-lasting.
Useful Information
Session duration
The treatment usually takes 20–30 minutes, depending on the area and skin needs.
Downtime
Patients may return to daily activities immediately. Mild redness, slight swelling or tenderness at injection points may occur and typically resolve within a few hours to one day.
Safety & possible side effects
Polynucleotides are considered one of the safest injectable treatments, as they are biocompatible, do not add volume and do not alter facial features.
Together, we’ll discover the best version of yourself!
Book your appointment today!Frequently Asked Questions (FAQs)
Is the treatment painful?
The procedure causes minimal discomfort. If the skin is sensitive, a topical anesthetic can be applied for extra comfort.
How many sessions are needed?
Typically, 2–3 sessions are recommended, spaced approximately 30 days apart. For more demanding areas, such as the under-eyes, additional reinforcement may be required.
What is the difference between polynucleotide mesotherapy and classic mesotherapy?
Classic mesotherapy hydrates and revitalizes the skin, while polynucleotides activate deeper regeneration mechanisms, improving the quality and structure of the skin at a deeper level.
Can polynucleotides be combined with other treatments?
Yes. They are often combined with microneedling, laser or Skin Boosters for even more comprehensive results, depending on the needs of the skin.
Do polynucleotides help with dark circles?
They can improve brightness and skin consistency, reducing the tired appearance. For darker, vascular circles, a combination with other treatments may be necessary.
Are polynucleotides suitable for all ages?
Yes. They benefit younger skin that needs hydration and stimulation, as well as mature skin with fine lines or loss of elasticity.