Hyaluronidase

The most direct and safe method to correct a hyaluronic acid filler that did not provide the desired result, restoring a natural appearance.

What is Hyaluronidase?

Hyaluronidase is an enzyme used for the targeted dissolution of hyaluronic acid from fillers.
It allows the doctor to remove or reduce unwanted product when complications or undesired outcomes occur, such as swelling, overcorrection, asymmetry or small nodules.

How Does it Correct an Unsuccessful Filler?

Hyaluronidase is injected precisely into the area of concern, breaking down the hyaluronic acid so that the body can absorb it immediately.
Its action begins within a few minutes, while the final result stabilizes within 24–48 hours, offering fast and controlled correction.

Hyaluronidase for the Lips

Hyaluronidase for the lips is used when a lip filler does not achieve the desired outcome.
It can correct asymmetry, excess volume, firm lumps (nodules) or a “heavy” appearance due to improper technique or overfilling.
With targeted application, only the necessary amount of hyaluronic acid is dissolved, helping reduce swelling and restore the natural lip contour.
The procedure is short, virtually painless and provides fast improvement without affecting the surrounding tissues.

Hyaluronidase Under the Eyes

The under-eye area is particularly delicate, therefore fillers in this region may more easily lead to swelling, puffiness, bluish discoloration (Tyndall effect), or asymmetries.

Hyaluronidase allows precise dissolution of the filler, reducing persistent swelling, improving the uniformity of the area and correcting filler that has migrated or been placed incorrectly.

Lumps & Granulomas After Hyaluronic Acid Fillers

Lumps or small granulomas that may appear after fillers are usually due to overfilling, incorrect technique, or a tissue reaction.
Hyaluronidase is the most effective solution for their dissolution, as it acts locally and precisely.
The treatment is indicated when the issue does not resolve on its own or when it causes aesthetic concern.

Hyaluronic Acid Dissolution – Step by Step

The hyaluronidase procedure is short, targeted and tailored to each patient’s needs. The goal is to dissolve exactly the amount of hyaluronic acid required, without affecting the surrounding tissues.

The main steps include:

Clinical evaluation of the area

The doctor examines the area, identifies the issue and determines the correct dose of hyaluronidase.

Topical anesthesia (if needed)

A topical anesthetic cream may be applied for greater comfort.

Targeted hyaluronidase injection

The enzyme is injected only in the areas that require correction to ensure precise dissolution.

Immediate observation of the effect

Initial improvement is often visible within the first few minutes.

Post-treatment instructions

Avoid applying strong pressure to the area and apply ice if mild swelling occurs.

Is the procedure safe?

Hyaluronidase is generally considered a safe and well-tolerated treatment when performed by a qualified medical professional.
Side effects are usually mild and temporary, limited to the injection site.

Possible side effects include:

• slight redness or tenderness
• minor swelling that resolves quickly
• temporary burning sensation

Hyaluronidase & Allergy – How likely is it?

Allergic reactions are extremely rare. The doctor evaluates the patient’s medical history and performs the treatment with full safety precautions.
In the unlikely event of a strong hypersensitivity reaction, immediate medical management is available at the clinic.

Why expertise matters

Hyaluronidase application requires precision, experience and a thorough understanding of how fillers behave within the tissues.
Dr. Makrygiorgis and his team at KM Plastic Surgery Clinic have extensive experience in correcting fillers in the lips, under-eye area and face, managing cases that require targeted and controlled filler dissolution.
For accurate information and personalized cost assessment:

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FAQs

Is hyaluronidase painful?
The procedure is short and generally well tolerated. If necessary, a topical anesthetic can be applied to ensure minimal discomfort.

How long does the session take?
The procedure takes approximately 10–15 minutes, depending on the area and the nature of the correction.

Does hyaluronidase dissolve all the filler or only the area that needs correction?
Hyaluronidase acts only in the area where it is injected. The doctor precisely adjusts the amount so that only the targeted filler is dissolved.

Is the result of dissolution permanent?
Yes. Once the hyaluronic acid is dissolved and absorbed, it does not return unless new filler is applied in the future.

Do I need any preparation before the treatment?
No special preparation is required. A brief clinical evaluation is sufficient prior to the procedure.

Can I have new filler after hyaluronidase?
Yes, you can. It is usually recommended to wait a few days until the area is fully stabilized before applying new filler.