What Are Polynucleotides?<\/h2>\n\n\n\n
Polynucleotides (PN\/PDRN) are pure, biocompatible DNA molecules that have the ability to stimulate the skin\u2019s natural regeneration mechanisms.
When injected into the superficial layers of the skin, they act as biostimulators that boost collagen production, support cellular renewal, improve microcirculation and increase dermal density.<\/p>\n\n\n\n
Benefits<\/h2>\n\n\n\n
Polynucleotides enhance the skin\u2019s natural regenerative processes, offering gradual and substantial improvement in skin quality.
Key benefits include:<\/p>\n\n\n\n
- \n
- increased elasticity and dermal density<\/li>\n\n\n\n
- improved texture and fine lines<\/li>\n\n\n\n
- brighter and more even complexion<\/li>\n\n\n\n
- enhanced hydration and natural glow<\/li>\n\n\n\n
- reduced dullness and signs of fatigue<\/li>\n<\/ul>\n<\/div>\n\n\n\n\n
![](\"https:\/\/makrygiorgisplasticsurgeon.com\/wp-content\/uploads\/2025\/12\/shutterstock_2683976533.jpg\" "\\"A,Professional,Aesthetician,Marking,A,Client,Face,With,A,Medical-grade\\"")
\n<\/div>\n<\/div>\n\n\n\n<\/div>\n\n\n\nPolynucleotide Treatment<\/h2>\n\n\n\n
This treatment does not alter facial features, does not add volume and is not used as a filler. Its purpose is to improve the structure, quality and function of the skin at a deeper level.<\/p>\n\n\n\n
<\/div>\n\n\n\nWhich Skin Concerns Does It Address?<\/h2>\n\n\n\n
Polynucleotide therapy is recommended when the skin shows loss of elasticity, dullness, dehydration, fine lines, mild laxity or uneven texture.
It is particularly effective on skin with reduced density, especially in the under-eye area and the face.<\/p>\n\n\n\n<\/div>\n\n\n\nPolynucleotides for the Under-Eye Area<\/h2>\n\n\n\n
The under-eye region has thin, delicate skin that often shows dehydration and surface laxity. Polynucleotides are an excellent option, as they reinforce tissue density and structure without adding volume, providing a brighter and more refreshed appearance.<\/p>\n\n\n\n
<\/div>\n\n\n\nTreatment Procedure \u2013 Step by Step<\/h2>\n\n\n\n
The procedure is short and tailored to the individual needs of the patient\u2019s skin.<\/p>\n\n\n\n
Clinical evaluation<\/strong><\/p>\n\n\n\n
The doctor examines the area, identifies the needs of the skin and determines the appropriate protocol.<\/p>\n\n\n\n
Skin preparation<\/strong><\/p>\n\n\n\n
The skin is cleansed and, if necessary, a topical anesthetic is applied for greater comfort.<\/p>\n\n\n\n
Targeted micro-injections<\/strong><\/p>\n\n\n\n
Polynucleotides are injected into specific points of the superficial dermal layers in order to act directly on renewal mechanisms.<\/p>\n\n\n\n
Completion & aftercare<\/strong><\/p>\n\n\n\n
The session ends with a soothing application. The patient may return to daily activities immediately.<\/p>\n\n\n\n
<\/div>\n\n\n\n\n\n\n![](\"https:\/\/makrygiorgisplasticsurgeon.com\/wp-content\/uploads\/2025\/03\/image00158.webp\")
\n<\/div>\n\n\n\n\nPlastic Surgeon Dr. Konstantinos Ch. Makrygiorgis<\/strong><\/h4>\n\n\n\n
Plastic surgery is the perfect blend of science and art<\/strong>, of passion and technology<\/strong>. Our primary goal is to help you achieve your personal aesthetic aspirations, while also providing you with clear and honest guidance for your benefit. Perfectionists by nature, we are fully committed to your vision to how you<\/strong> imagine your best self. Because perfection is a deeply personal matter<\/strong>, and it doesn’t come in one single form.<\/p>\n\n\n\nLearn more about the Doctor<\/a>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n\nTreatment Results<\/h2>\n\n\n\n
Polynucleotides provide gradual, natural and high-quality results, as they act on the skin\u2019s regeneration mechanisms.<\/p>\n\n\n\n
When are results visible?<\/h3>\n\n\n\n
Initial improvements become noticeable within 7\u201310 days, with the skin appearing more hydrated and even. Full results develop gradually over the next 4\u20136 weeks as collagen production increases and tissue density improves.<\/p>\n\n\n\n
How long do results last?<\/h3>\n\n\n\n
Results typically last 6\u20139 months, depending on skin type and treatment protocol. With regular maintenance sessions, improvement becomes even more stable and long-lasting.<\/p>\n\n\n\n
<\/div>\n\n\n\nUseful Information<\/h2>\n\n\n\n
Session duration<\/h3>\n\n\n\n
The treatment usually takes 20\u201330 minutes, depending on the area and skin needs.<\/p>\n\n\n\n
Downtime<\/h3>\n\n\n\n
Patients may return to daily activities immediately. Mild redness, slight swelling or tenderness at injection points may occur and typically resolve within a few hours to one day.<\/p>\n\n\n\n
Safety & possible side effects<\/h3>\n\n\n\n
Polynucleotides are considered one of the safest injectable treatments, as they are biocompatible, do not add volume and do not alter facial features.<\/p>\n\n\n\n